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Peer-Reviewed Publication
Comput Methods Programs Biomed2024;245108035.March 1, 2024Journal Article

Kidney cortex shear wave motion simulations based on segmented biopsy histology.

Luiz Vasconcelos1, Piotr Kijanka2, Joseph P Grande3, Rebeca Oliveira4, Carolina Amador5, Sara Aristizabal6, Nicholas M Sanger7, Andrew D Rule8, Thomas D Atwell9, Matthew W Urban9
1Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: vasconcelos.luiz@mayo.edu.
2Department of Robotics and Mechatronics, AGH University of Krakow, Krakow, Poland.
3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
4Department of Earth and Environmental Sciences, University of Minnesota, Minneapolis, MN, USA.
5Butterfly Network, Inc., Burlington, MA, USA.
6Delos Living, New York, NY, USA.
7Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.
8Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
9Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Abstract

BACKGROUND AND OBJECTIVE: Biopsy stands as the gold standard for kidney transplant assessment, yet its invasive nature restricts frequent use. Shear wave elastography (SWE) is emerging as a promising alternative for kidney transplant monitoring. A parametric study involving 12 biopsy data sets categorized by standard biopsy scores (3 with normal histology, 3 with interstitial inflammation (i), 3 w…

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