Determining the impact of an artificial intelligence tool on the management of pulmonary nodules detected incidentally on CT (DOLCE) study protocol: a prospective, non-interventional multicentre UK study.

Emma O'Dowd¹, Marko Berovic², Matthew Callister³, Christos V Chalitsios⁴, Disha Chopra⁵, Indrajeet Das⁶, Adrian Draper⁷, Justin L Garner⁸, Fergus Gleeson⁹, Sam Janes¹⁰, Martyn Kennedy³, Richard Lee¹¹, Fabrizio Mauri⁵, Tricia M McKeever⁴, William McNulty², James Murray¹², Arjun Nair¹³, John Park⁹, Janette Rawlinson¹⁴, Gurdeep Singh Sagoo¹⁵, Andrew Scarsbrook³, Pallav Shah¹⁶, Rajini Sudhir⁶, Ambika Talwar⁹, Ricky Thakrar¹⁷, Johnathan Watkins⁵, David R Baldwin¹⁸

¹Nottingham University Hospitals NHS Trust, Nottingham, UK emma.o'dowd@nottingham.ac.uk.

²King's College Hospital NHS Foundation Trust, London, UK.

³Leeds Teaching Hospitals NHS Trust, Leeds, UK.

⁴University of Nottingham, Nottingham, UK.

⁵Optellum Ltd, Oxford, UK.

⁶University Hospitals of Leicester NHS Trust, Leicester, UK.

⁷Respiratory Medicine, St George's Hospital, London, UK.

⁸Royal Brompton and Harefield Hospitals, London, UK.

⁹Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

¹⁰University College London, London, UK.

¹¹Royal Marsden Hospital NHS Trust, London, UK.

¹²Royal Free London NHS Foundation Trust, London, UK.

¹³University College Hospital, London, UK.

¹⁴Consumer Forum, NCRI CSG (lung) Subgroup, BTOG Steering Committee, NHSE CEG, National Cancer Research Institute, London, UK.

¹⁵Population Health Sciences Institute, University of Newcastle, Newcastle upon Tyne, UK.

¹⁶Royal Brompton and Harefield NHS Foundation Trust, London, UK.

¹⁷University College London Hospitals NHS Foundation Trust, London, UK.

¹⁸Nottingham University Hospitals NHS Trust, Nottingham, UK.

PubMed PMC DOI PDF

Abstract

INTRODUCTION: In a small percentage of patients, pulmonary nodules found on CT scans are early lung cancers. Lung cancer detected at an early stage has a much better prognosis. The British Thoracic Society guideline on managing pulmonary nodules recommends using multivariable malignancy risk prediction models to assist in management. While these guidelines seem to be effective in clinical practice…

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