Peer-Reviewed Publication
Am J Respir Crit Care Med2024;209(10):1196-1207.May 15, 2024Journal Article
A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
Clarus Leung1, Monica Tang1, Brendan K Huang1, Sean B Fain2, Eric A Hoffman2, Jiwoong Choi3, Eleanor M Dunican4, David T Mauger5, Loren C Denlinger6, Nizar N Jarjour6, Elliot Israel7, Bruce D Levy7, Sally E Wenzel8, Kaharu Sumino9, Annette T Hastie10, Joshua Schirm11, Charles E McCulloch12, Michael C Peters1, Prescott G Woodruff1,13, Ronald L Sorkness14, Mario Castro3, John V Fahy1,13
1Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.
2Department of Radiology, University of Iowa, Iowa City, Iowa.
3Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
4School of Medicine, University College Dublin, Dublin, Ireland.
5Division of Biostatistics and Bioinformatics, Penn State College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania.
6Division of Allergy, Pulmonary, and Critical Care Medicine, School of Medicine and Public Health, and.
7Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
8Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
9Division of Pulmonary and Critical Care Medicine, Washington University, St. Louis, Missouri.
10Section for Pulmonary, Critical Care, Allergy and Immunology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
11VIDA Diagnostics Inc., Coralville, Iowa.
12Department of Epidemiology and Biostatistics, and.
13Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California.
14School of Pharmacy, University of Wisconsin, Madison, Wisconsin.
Abstract
Rationale: Density thresholds in computed tomography (CT) lung scans quantify air trapping (AT) at the whole-lung level but are not informative for AT in specific bronchopulmonary segments. Objectives: To apply a segment-based measure of AT in asthma to investigate the clinical determinants of AT in asthma. Methods: In each of 19 bronchopulmonary segments in CT lung scans from 199 patients with as…
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