Hepatocyte-specific regulation of autophagy and inflammasome activation via MyD88 during lethal Ehrlichia infection.

Omid Teymournejad¹, Aditya Kumar Sharma¹, Mohammed Abdelwahed^1,2, Muhamuda Kader³, Ibrahim Ahmed¹, Hoda Elkafas¹, Nahed Ismail¹

¹Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.

²Hofstra School of Medicine, North Well Health, New York, NY, United States.

³Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

PubMed PMC DOI PDF

Abstract

Hepatocytes play a crucial role in host response to infection. Ehrlichia is an obligate intracellular bacterium that causes potentially life-threatening human monocytic ehrlichiosis (HME) characterized by an initial liver injury followed by sepsis and multi-organ failure. We previously showed that infection with highly virulent Ehrlichia japonica (E. japonica) induces liver damage and fatal ehrlic…

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