Peer-Reviewed Publication
BMC Nephrol2023;24(1):339.November 14, 2023Journal Article
Associations between abrupt transition, dialysis-requiring AKI, and early mortality in ESKD among U.S. veterans.
Raymond K Hsu1, Anna D Rubinsky2, Michael G Shlipak3, Kirsten L Johansen4,5, Michelle M Estrella6,3, Benjamin J Lee7,8, Carmen A Peralta6,3,9, Chi-Yuan Hsu6
1Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. raymond.hsu@ucsf.edu.
2Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
3Department of Medicine, Kidney Health Research Collaborative, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
4Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, MN, USA.
5Division of Nephrology, Hennepin Healthcare, Minneapolis, MN, USA.
6Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
7Houston Methodist Institute for Academic Medicine, Houston, TX, USA.
8Houston Kidney Consultants, Houston, TX, USA.
9Cricket Health, Inc, San Francisco, CA, USA.
Abstract
BACKGROUND: Mortality is high within the first few months of starting chronic dialysis. Pre-ESKD trajectory of kidney function has been shown to be predictive of early death after dialysis initiation. We aim to better understand how two key aspects of pre-dialysis kidney function-an abrupt transition pattern and an episode of dialysis-requiring AKI (AKI-D) leading directly to ESKD-are associated w…
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