A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength.

Mark S Shiroishi^1,2,3, Dane Weinert¹, Steven Y Cen¹, Bino Varghese¹, Timothy Dondlinger⁴, Melissa Prah⁵, Jesse Mendoza¹, Sina Nazemi¹, Nima Ameli¹, Negin Amini¹, Salman Shohas¹, Shannon Chen¹, Bavrina Bigjahan¹, Gabriel Zada⁶, Thomas Chen⁶, Josh Neman-Ebrahim⁶, Eric L Chang⁷, Frances E Chow⁶, Zhaoyang Fan^1,7, Wensha Yang⁷, Frank J Attenello⁶, Jason Ye⁷, Paul E Kim¹, Vishal N Patel⁸, Alexander Lerner¹, Jay Acharya¹, Leland S Hu⁹, C Chad Quarles¹⁰, Jerrold L Boxerman¹¹, Ona Wu¹², Kathleen M Schmainda⁵

¹Department of Radiology, Keck School of Medicine of the University of Southern California (USC), Los Angeles, CA, United States.

²Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, United States.

³Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, United States.

⁴Imaging Biometrics, Elm Grove, WI, United States.

⁵Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States.

⁶Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA, United States.

⁷Department of Radiation Oncology, Keck School of Medicine of USC, Los Angeles, CA, United States.

⁸Department of Radiology, Mayo Clinic, Jacksonville, FL, United States.

⁹Department of Radiology, Mayo Clinic, Phoenix, AZ, United States.

¹⁰Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

¹¹Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, RI, United States.

¹²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

PubMed PMC DOI PDF

Abstract

INTRODUCTION: 1.5 Tesla (1.5T) remain a significant field strength for brain imaging worldwide. Recent computer simulations and clinical studies at 3T MRI have suggested that dynamic susceptibility contrast (DSC) MRI using a 30° flip angle ("low-FA") with model-based leakage correction and no gadolinium-based contrast agent (GBCA) preload provides equivalent relative cerebral blood volume (rCBV) m…

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Mentioned Companies

IMAGING BIOMETRICS
affiliation

NIH Funding

Grant #10679035
Advanced prediction of GBM recurrence (TIME) for personalized radiotherapy
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
$179,860 (FY2024)

Other Funding

NCI NIH HHS(R21 CA267139)
United States
NCI NIH HHS(R01 CA221938)
United States
NCI NIH HHS(R01 CA213158)
United States
NCI NIH HHS(U01 CA176110)
United States
NCI NIH HHS(R01 CA255123)
United States

Keywords

1.5 Tesladynamic susceptibility contrast MRI (DSC-MRI)flip anglegliomastandardization

Article Info

PMID: 37799462
PMCID: PMC10548232
DOI: 10.3389/fonc.2023.1156843
Received: February 1, 2023
Accepted: August 21, 2023

How to Cite

Shiroishi MS et al. A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength. Front Oncol2023;131156843. doi:10.3389/fonc.2023.1156843

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