Peer-Reviewed Publication
Nat Commun2023;14(1):6066.September 28, 2023Journal Article
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures.
Leland S Hu1,2,3, Fulvio D'Angelo4, Taylor M Weiskittel5,6, Francesca P Caruso7,8, Shannon P Fortin Ensign9,10, Mylan R Blomquist9,6,11, Matthew J Flick12,9,11, Lujia Wang13, Christopher P Sereduk9,14, Kevin Meng-Lin6, Gustavo De Leon14, Ashley Nespodzany15, Javier C Urcuyo14, Ashlyn C Gonzales15, Lee Curtin14, Erika M Lewis16, Kyle W Singleton14, Timothy Dondlinger17, Aliya Anil15, Natenael B Semmineh18, Teresa Noviello7,8, Reyna A Patel12, Panwen Wang19, Junwen Wang20, Jennifer M Eschbacher21, Andrea Hawkins-Daarud14, Pamela R Jackson14, Itamar S Grunfeld22,23, Christian Elrod24, Gina L Mazza19, Sam C McGee25, Lisa Paulson14, Kamala Clark-Swanson14, Yvette Lassiter-Morris14, Kris A Smith26, Peter Nakaji27, Bernard R Bendok14, Richard S Zimmerman14, Chandan Krishna14, Devi P Patra14, Naresh P Patel14, Mark Lyons14, Matthew Neal14, Kliment Donev28, Maciej M Mrugala29, Alyx B Porter29, Scott C Beeman16, Todd R Jensen30, Kathleen M Schmainda31, Yuxiang Zhou12, Leslie C Baxter12,32, Christopher L Plaisier16, Jing Li13, Hu Li6, Anna Lasorella33, C Chad Quarles18, Kristin R Swanson9,14, Michele Ceccarelli34, Antonio Iavarone35, Nhan L Tran36,37
1Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA. hu.leland@mayo.edu.
2Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA. hu.leland@mayo.edu.
3Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA. hu.leland@mayo.edu.
4Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. fxd317@med.miami.edu.
5Mayo Clinic Alix School of Medicine Minnesota, Rochester, MN, USA.
6Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
7Department of Electrical Engineering and Information Technologies, University of Naples, "Federico II", I-80128, Naples, Italy.
8BIOGEM Institute of Molecular Biology and Genetics, I-83031, Ariano Irpino, Italy.
9Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
10Department of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
11Mayo Clinic Alix School of Medicine Arizona, Scottsdale, AZ, USA.
12Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA.
13H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
14Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA.
15Department of Neuroimaging Research, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA.
16School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
17Imaging Biometrics, LLC, Elm Grove, Milwaukee, USA.
18Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
19Quantitative Health Sciences, Mayo Clinic Arizona, Scottsdale, AZ, USA.
20Division of Applied Oral Sciences & Community Dental Care, The University of Hong Kong, Hong Kong SAR, China.
21Department of Neuropathology, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA.
22Department of Psychology, Hunter College, The City University of New York, New York, NY, USA.
23Department of Psychology, The Graduate Center, The City University of New York, New York, NY, USA.
24Avinger Incorporated, Redwood City, CA, USA.
25Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
26Department of Neurosurgery, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA.
27Department of Neurosurgery, Banner University Medical Center, University of Arizona, Phoenix, AZ, USA.
28Department of Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA.
29Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA.
30Jensen Informatics LLC, Shorewood, WI, USA.
31Departments of Biophysics and Radiology, Medical College of Wisconsin, Milwaukee, WI, USA.
32Departments of Psychiatry and Psychology, Mayo Clinic, AZ, USA.
33Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
34Department of Public Health Sciences, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. mxc2982@miami.edu.
35Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. axi435@med.miami.edu.
36Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA. Tran.Nhan@mayo.edu.
37Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA. Tran.Nhan@mayo.edu.
Abstract
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional tumor biopsies, including 111 from the NE, across 68 HGG patients. Wh…
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