Initial experience with an electron FLASH research extension (FLEX) for the Clinac system.

Kyuhak Oh¹, Kyle J Gallagher¹, Megan Hyun¹, Diane Schott¹, Sarah Wisnoskie¹, Yu Lei¹, Samuel Hendley¹, Jeffrey Wong¹, Shuo Wang¹, Brendan Graff¹, Christopher Jenkins¹, Frank Rutar¹, Md Ahmed², Joshua McNeur², Jeffrey Taylor², Marty Schmidt², Lasitha Senadheera², Wendy Smith², Donald Umstadter³, Subodh M Lele¹, Ran Dai¹, Dong Jianghu James¹, Ying Yan¹, Zhou Su-Min¹

¹University of Nebraska Medical Center, Omaha, Nebraska, USA.

²Varian Medical Systems, Palo Alto, California, USA.

³University of Nebraska, Lincoln, Nebraska, USA.

PubMed PMC DOI PDF

Abstract

PURPOSE: Radiotherapy delivered at ultra-high-dose-rates (≥40 Gy/s), that is, FLASH, has the potential to effectively widen the therapeutic window and considerably improve the care of cancer patients. The underlying mechanism of the FLASH effect is not well understood, and commercial systems capable of delivering such dose rates are scarce. The purpose of this study was to perform the initial acce…

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