Predicting the BRAF mutation with pretreatment MRI radiomics features for melanoma brain metastases receiving Gamma Knife radiosurgery.

D Kawahara¹, A Jensen², J Yuan³, Y Nagata⁴, Y Watanabe³

¹Department of Radiation Oncology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: daika99@hiroshima-u.ac.jp.

²RADformation, New York, NY, USA.

³Department of Radiation Oncology, University of Minnesota-Twin Cities, Minneapolis, MN, USA.

⁴Department of Radiation Oncology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

PubMed DOI

Abstract

AIM: To develop a model using radiomics features extracted from magnetic resonance imaging (MRI) images of Gamma Knife radiosurgery (GKRS) to predict the BRAF mutation in patients with melanoma brain metastases (MBM). MATERIALS AND METHODS: Data of 220 tumours were classified into two groups. One was a group whose BRAF mutation was identified, and the other group whose BRAF mutation was not ident…

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