C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans.

Julian C Bachmann¹, Jeppe E Kirchhoff¹, Julia E Napolitano², Steve Sorota², William M Gordon², Nicole Feric², Roozbeh Aschar-Sobbi², Juan Lv¹, Zhiyou Cao¹, Ken Coppieters¹, Giulia Borghetti¹, Michael Nyberg¹

¹Research & Early Development, Novo Nordisk A/S, Maaloev, Denmark.

²Valo Health, Boston, MA, USA.

PubMed PMC DOI PDF

Abstract

The role of C-type natriuretic peptide (CNP) in the regulation of cardiac function in humans remains to be established as previous investigations have been confined to animal model systems. Here, we used well-characterized engineered cardiac tissues (ECTs) generated from human stem cell-derived cardiomyocytes and fibroblasts to study the acute effects of CNP on contractility. Application of CNP el…

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