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Peer-Reviewed Publication
JACC Heart Fail2023;11(10):1351-1362.October 1, 2023Randomized Controlled Trial

Atrial Fibrillation Burden and Atrial Shunt Therapy in Heart Failure With Preserved Ejection Fraction.

Ravi B Patel1, Vivek Y Reddy2, Jan Komtebedde3, Stephan W Wegerich4, Jadranka Sekaric4, Vijay Swarup5, Antony Walton6, Gabriel Laurent7, Stanley Chetcuti8, Matthias Rademann9, Martin Bergmann10, Scott McKenzie11, Heiko Bugger12, Raphael Romano Bruno13, Howard C Herrmann14, Ajith Nair15, Deepak K Gupta16, Scott Lim17, Samir Kapadia18, Robert Gordon19, Marc Vanderheyden20, Thomas Noel21, Steven Bailey22, Zachary M Gertz23, Jean-Noël Trochu24, Donald E Cutlip25, Martin B Leon26, Scott D Solomon27, Dirk J van Veldhuisen28, Angelo Auricchio29, Sanjiv J Shah30
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Illinois, USA.
2Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
3Corvia Medical, Inc., Tewksbury, Massachusetts, USA.
4physIQ Inc., Chicago, Illinois, USA.
5Arizona Hearth Rhythm, Phoenix, Arizona, USA.
6Heart Centre, Alfred Health, Melbourne, Australia.
7Department of Cardiology, Dijon University Hospital, Dijon, France.
8Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
9Department of Cardiology, University of Giessen, Bad Nauheim, Germany.
10Department of Interventional Cardiology, Cardiologicum, Hamburg, Germany.
11School of Medicine, University of Queensland, The Prince Charles Hospital, Brisbane, Australia.
12Division of Cardiology, Medical University of Graz, Graz, Austria.
13Division of Cardiology, Pulmonology, and Vascular Medicine, Faculty of Medicine, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
14Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Division of Cardiology, Baylor College of Medicine, Houston, Texas, USA.
16Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
17Division of Cardiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
18Division of Cardiology, Cleveland Clinic, Cleveland, Ohio, USA.
19Division of Cardiology, NorthShore University Health System, Evanston, Illinois, USA.
20Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium.
21Southern Medical Group, P.A., Tallahassee, Florida, USA.
22Division of Cardiology, Louisiana State University School of Medicine, Baton Rouge, Louisiana, USA.
23Division of Cardiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
24Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
25Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
26Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, New York, USA.
27Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
28Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
29Division of Cardiology, Ticino Cardiocentro Institute, Lugano, Switzerland.
30Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: sanjiv.shah@northwestern.edu.
PubMed DOI

Abstract

BACKGROUND: Atrial fibrillation (AF) is a common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF) and in heart failure with mildly reduced ejection fraction (HFmrEF). OBJECTIVES: This study sought to describe AF burden and its clinical impact among individuals with HFpEF and HFmrEF who participated in a randomized clinical trial of atrial shunt therapy (REDUCE L…

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