[Pachymic acid protects against Crohn's disease-like intestinal barrier injury and colitis in miceby suppressingintestinal epithelial cell apoptosis via inhibiting PI3K/AKT signaling].

R Shao¹, Z Yang^2,3, W Zhang⁴, N Zhang⁴, Y Zhao^2,5, X Zhang⁶, L Zuo³, S Ge³

¹Cardiogram Room, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

²Clinical Medical School, Bengbu 233000, China.

³Department of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

⁴Department of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

⁵Anhui Provincial Key Laboratory of Tissue Transplantation, Bengbu 233000, China.

⁶Central Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: To investigate the effect of pachymic acid (PA) against TNBS-induced Crohn's disease (CD)-like colitis in mice and explore the possible mechanism. METHODS: Twenty-four C57BL/6J mice were randomized equally into control group, TNBS-induced colitis model group and PA treatment group. PA treatment was administered via intraperitoneal injection at the daily dose of 5 mg/kg for 7 days, and…

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