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Peer-Reviewed Publication
Retrovirology2023;20(1):5.May 1, 2023Journal Article

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells.

Ming-Han C Tsai1,2, Sarah J Caswell3,4, Elizabeth R Morris3,5, Melanie C Mann1,6, Simon Pennell7,8, Geoff Kelly9, Harriet C T Groom1,10, Ian A Taylor3, Kate N Bishop11
1Retroviral Replication Laboratory, The Francis Crick Institute, London, UK.
2LabGenius, London, UK.
3Macromolecular Structure Laboratory, The Francis Crick Institute, London, UK.
4AstraZeneca, Granta Park, Cambridge, UK.
5Department of Biosciences, University of Durham, Durham, UK.
6Sartorius, Ulm, Germany.
7Structural Biology of DNA-Damage Signalling Laboratory, The Francis Crick Institute, London, UK.
8MRC London Institute of Medical Sciences, London, UK.
9The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute, London, UK.
10Department of Medicine, University of Cambridge, Cambridge, UK.
11Retroviral Replication Laboratory, The Francis Crick Institute, London, UK. kate.bishop@crick.ac.uk.
PubMed PMC DOI PDF

Abstract

BACKGROUND: SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells inactivating the enzymatic activity. To distinguish between theories for how SAMHD1 restricts HIV-1 in differentiated but not cycling cells…

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