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Peer-Reviewed Publication
Br J Neurosurg2025;39(2):173-179.April 1, 2025Journal Article

NF2 mutation associated with accelerated time to recurrence for older patients with atypical meningiomas.

Jonathan T Dullea1, Danielle Chaluts1, Vikram Vasan1, John W Rutland1, Corey M Gill1, Ethan Ellis2, Yayoi Kinoshita3, Russell B McBride3,4, Joshua Bederson1, Michael Donovan3, Robert Sebra2,5, Melissa Umphlett3, Raj K Shrivastava1
1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
3Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
4The Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
5Sema4, A Mount Sinai venture, Stamford, CT.
PubMed PMC DOI PDF

Abstract

PURPOSE: Meningiomas occur more frequently in older adults, with the incidence rates increasing from 5.8/100,000 for adults 35-44 years old to 55.2/100,000 for those 85+. Due to the increased risk of surgical management in older adults, there is a need to characterize the risk factors for aggressive disease course to inform management decisions in this population. We therefore sought to determine…

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