Synthesis of Carvone Derivatives and In Silico and In Vitro Screening of Anti-Inflammatory Activity in Murine Macrophages.

Gabriela Moço^1,2,3, Cátia Sousa^2,4, Ana Capitão^2,3,4, Stephen Scott MacKinnon⁵, Alcino Jorge Leitão^1,2,3, Alexandrina Ferreira Mendes^1,2,3

¹Faculty of Pharmacy, University of Coimbra, 3004-548 Coimbra, Portugal.

²Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

³Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.

⁴Interdisciplinary Research Institute, University of Coimbra, 3030-789 Coimbra, Portugal.

⁵Cyclica Inc., Toronto, ON M5J 1A7, Canada.

PubMed PMC DOI PDF

Abstract

The chemical modification of natural compounds is a promising strategy to improve their frequently poor bioavailability and low potency. This study aimed at synthesizing chemical derivatives of carvone, a natural monoterpene with anti-inflammatory properties, which we recently identified, and evaluating their potential anti-inflammatory activity. Fourteen chemical derivatives of carvone were synth…

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Mentioned Companies

Cyclica
affiliation

Other Funding

Fundação para a Ciência e Tecnologia(POCI-01-0145-FEDER-028424)
Fundação para a Ciência e Tecnologia(UIDB/04539/2020)
Fundação para a Ciência e Tecnologia(UIDP/04539/2020)
Fundação para a Ciência e Tecnologia(LA/P/0058/2020)

MeSH Terms

Mice0Animals0Ligands0Nitric Oxide Synthase Type II0Anti-Inflammatory Agents*Macrophages*RAW 264.7 Cells0Nitric Oxide0Lipopolysaccharides0Cyclohexane Monoterpenes0

Keywords

8- and/or 9-substituted carvone derivativesanti-inflammatory activitycarvonechemical synthesischronic inflammation

Article Info

PMID: 36768590
PMCID: PMC9916994
DOI: 10.3390/ijms24032263
Received: December 31, 2022
Accepted: January 17, 2023

How to Cite

Moço G et al. Synthesis of Carvone Derivatives and In Silico and In Vitro Screening of Anti-Inflammatory Activity in Murine Macrophages. Int J Mol Sci2023;24(3) doi:10.3390/ijms24032263

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