Longitudinal Assessment of Multiple Sclerosis Lesion Load With Synthetic Magnetic Resonance Imaging-A Multicenter Validation Study.

Sarah Schlaeger¹, Hongwei Bran Li, Thomas Baum¹, Claus Zimmer¹, Julia Moosbauer², Sebastian Byas², Mark Mühlau³, Benedikt Wiestler¹, Tom Finck¹

¹From the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar.

²Deepc GmbH.

³Department of Neurology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

PubMed DOI

Abstract

INTRODUCTION: Double inversion recovery (DIR) has been validated as a sensitive magnetic resonance imaging (MRI) contrast in multiple sclerosis (MS). Deep learning techniques can use basic input data to generate synthetic DIR (synthDIR) images that are on par with their acquired counterparts. As assessment of longitudinal MRI data is paramount in MS diagnostics, our study's purpose is to evaluate…

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