NS-HGlio: A generalizable and repeatable HGG segmentation and volumetric measurement AI algorithm for the longitudinal MRI assessment to inform RANO in trials and clinics.

Aly H Abayazeed¹, Ahmed Abbassy¹, Michael Müeller^1,2, Michael Hill¹, Mohamed Qayati^1,3, Shady Mohamed^1,3, Mahmoud Mekhaimar³, Catalina Raymond⁴, Prachi Dubey⁵, Kambiz Nael⁶, Saurabh Rohatgi⁷, Vaishali Kapare⁸, Ashwini Kulkarni⁸, Tina Shiang⁸, Atul Kumar⁹, Nicolaus Andratschke¹⁰, Jonas Willmann¹⁰, Alexander Brawanski^3,11, Reordan De Jesus¹², Ibrahim Tuna¹², Steve H Fung⁵, Joseph C Landolfi¹³, Benjamin M Ellingson⁴, Mauricio Reyes²

¹Biomedical Engineering group, Neosoma Inc., Groton, Massachusetts, USA (Originating Institution address:44 Farmers Row, Groton, Massachusetts, 01450), USA.

²ARTORG Biomedical Engineering group, University of Bern, Switzerland.

³Radiology Department, University of Cairo School of Medicine, Egypt.

⁴Brain Tumor Imaging Laboratory, University of California Los Angeles, Los Angeles, California, USA.

⁵Radiology Department, Houston Methodist Hospital, Houston, Texas, USA.

⁶Radiology Department, University of California Los Angeles, Los Angeles, California, USA.

⁷Radiology Department, Massachusetts General Hospital, Boston, Massachusetts, USA.

⁸Radiology Department, University of Massachusetts, Worcester, Massachusetts, USA.

⁹Radiology Department, Yale School of Medicine, New Haven, Connecticut, USA.

¹⁰Radiation Oncology Department, University of Zurich, Switzerland.

¹¹Radiation Oncology Department, University Hospital Regensburg, Cairo Egypt and Regensburg, Germany.

¹²Radiology Department, University of Florida, Gainesville, Florida, USA.

¹³Neurology/Neuro-oncology Department, Hackensack Meridian Health JFK Medical Center, Edison, New Jersey, USA.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Accurate and repeatable measurement of high-grade glioma (HGG) enhancing (Enh.) and T2/FLAIR hyperintensity/edema (Ed.) is required for monitoring treatment response. 3D measurements can be used to inform the modified Response Assessment in Neuro-oncology criteria. We aim to develop an HGG volumetric measurement and visualization AI algorithm that is generalizable and repeatable. METH…

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