Is the generalizability of a developed artificial intelligence algorithm for COVID-19 on chest CT sufficient for clinical use? Results from the International Consortium for COVID-19 Imaging AI (ICOVAI).

Laurens Topff^1,2, Kevin B W Groot Lipman^3,4,5, Frederic Guffens⁶, Rianne Wittenberg³, Annemarieke Bartels-Rutten³, Gerben van Veenendaal⁷, Mirco Hess⁷, Kay Lamerigts⁷, Joris Wakkie⁷, Erik Ranschaert^8,9, Stefano Trebeschi³, Jacob J Visser¹⁰, Regina G H Beets-Tan^3,4,11,

¹Department of Radiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands. l.topff@nki.nl.

²GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. l.topff@nki.nl.

³Department of Radiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

⁴GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.

⁵Department of Thoracic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

⁶Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

⁷Aidence, Amsterdam, The Netherlands.

⁸Department of Radiology, St. Nikolaus Hospital, Hufengasse 4-8, 4700, Eupen, Belgium.

⁹Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.

¹⁰Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.

¹¹Institute of Regional Health Research, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.

PubMed PMC DOI PDF

Abstract

OBJECTIVES: Only few published artificial intelligence (AI) studies for COVID-19 imaging have been externally validated. Assessing the generalizability of developed models is essential, especially when considering clinical implementation. We report the development of the International Consortium for COVID-19 Imaging AI (ICOVAI) model and perform independent external validation. METHODS: The ICOVA…

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