Noninvasive Evaluation of Cardiac Chamber Pressures Using Subharmonic-Aided Pressure Estimation With Definity Microbubbles.

Cara Esposito¹, Priscilla Machado¹, Maureen E McDonald², Michael P Savage³, David Fischman³, Praveen Mehrotra³, Ira S Cohen³, Nicholas Ruggiero³, Paul Walinsky³, Alec Vishnevsky³, Kristopher Dickie⁴, Marguerite Davis³, Flemming Forsberg¹, Jaydev K Dave⁵

¹Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

²Medical Imaging and Radiation Sciences, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

³Cardiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

⁴Clarius Mobile Health, Vancouver, British Columbia, Canada.

⁵Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address: jaydev.dave@jefferson.edu.

PubMed DOI

Abstract

BACKGROUND: Noninvasive and accurate assessment of intracardiac pressures has remained an elusive goal of noninvasive cardiac imaging. OBJECTIVES: The purpose of this study was to investigate if errors in intracardiac pressures obtained noninvasively using contrast microbubbles and the subharmonic-aided pressure estimation (SHAPE) technique are <5 mm Hg. METHODS: In a nonrandomized institutional…

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Mentioned Companies

Clarius Mobile Health
affiliation

NIH Funding

Grant #9260041
Noninvasive real-time intracardiac pressure measurements using subharmonic ultrasound
THOMAS JEFFERSON UNIVERSITY
$195,000 (FY2017)

Other Funding

NHLBI NIH HHS(R21 HL130899)
United States

MeSH Terms

Humans0Ultrasonography0Microbubbles*Contrast Media*Predictive Value of Tests0Cardiac Catheterization0Fluorocarbons0

Keywords

intracardiac pressuresmicrobubblesnoninvasive pressuressubharmonic aided pressure estimationultrasound contrast agents

Article Info

PMID: 36648035
DOI: 10.1016/j.jcmg.2022.09.013
Received: March 11, 2022
Accepted: September 16, 2022

How to Cite

Esposito C et al. Noninvasive Evaluation of Cardiac Chamber Pressures Using Subharmonic-Aided Pressure Estimation With Definity Microbubbles. JACC Cardiovasc Imaging2023;16(2):224-235. doi:10.1016/j.jcmg.2022.09.013

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