Baseline serum Mac-2 binding protein glycosylation isomer as a predictor of hepatocellular carcinoma in chronic hepatitis B patients: a systematic review and meta-analysis.

Andro Pramana Witarto¹, Bendix Samarta Witarto¹, Shidi Laras Pramudito¹, Achmad Januar Er Putra¹, Grace Manuela Nurhadi¹, Ummi Maimunah²

¹Medical Program, Faculty of Medicine, Universitas Airlangga (Andro Pramana Witarto, Bendix Samarta Witarto, Shidi Laras Pramudito, Achmad Januar Er Putra, Grace Manuela Nurhadi).

²Gastroenterology and Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital (Ummi Maimunah), Surabaya, Indonesia.

PubMed PMC DOI PDF

Abstract

BACKGROUND: A minimally invasive tool to promptly predict hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) is currently needed. In this study, we aimed via a meta-analysis to identify the serum Mac-2 binding protein glycosylation isomer (M2BPGi) as a novel glycoprotein-based liver fibrosis marker for predicting HCC in CHB patients. METHODS: We conducted a systematic search on PubMed, S…

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