Photoredox Activation of Anhydrides for the Solvent-Controlled Switchable Synthesis of gem-Difluoro Compounds.

Rahul Giri¹, Ivan Mosiagin¹, Ivan Franzoni^2,3, Nicolas Yannick Nötel⁴, Subrata Patra¹, Dmitry Katayev¹

¹Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700, Fribourg, Switzerland.

²NuChem Sciences Inc., 2350 Rue Cohen, Suite 201, Saint-Laurent, Quebec, H4R 2N6, Canada.

³Present address: Valence Discovery Inc., 6666 Rue St-Urbain, Suite 200, Montreal, Quebec, H2S 3H1, Canada.

⁴Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg, 8093, Zürich, Switzerland.

PubMed PMC DOI PDF

Abstract

The incorporation of the gem-difluoromethylene (CF2 ) group into organic frameworks is highly sought due to the influence of this unit on the physicochemical and pharmacological properties of molecules. Herein we report an operationally simple, mild, and switchable protocol to access various gem-difluoro compounds that employs chlorodifloroacetic anhydride (CDFAA) as a low-cost and versatile fluor…

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