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Peer-Reviewed Publication
AIDS Behav2023;27(2):719-732.February 1, 2023Randomized Controlled Trial

Randomized Controlled Trial of Automated Directly Observed Therapy for Measurement and Support of PrEP Adherence Among Young Men Who have Sex with Men.

Susan P Buchbinder1,2,3,4, Aaron J Siegler5, Kenneth Coleman6, Eric Vittinghoff7, Gretchen Wilde5, Annie Lockard5, Hyman Scott6,8, Peter L Anderson9, Nicole Laborde10, Ariane van der Straten8,11, Richard H Christie12, Michelle Marlborough12, Albert Y Liu6,8
1Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA. susan.buchbinder@sfdph.org.
2Department of Medicine, University of California San Francisco, San Francisco, CA, USA. susan.buchbinder@sfdph.org.
3Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. susan.buchbinder@sfdph.org.
4Bridge HIV, San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 100, San Francisco, CA, 94102, USA. susan.buchbinder@sfdph.org.
5Department of Epidemiology, Emory University, Atlanta, GA, USA.
6Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
7Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
8Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
9University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
10Independent Consultant, San Rafael, USA.
11ASTRA Consulting, Kensington, CA, USA.
12AiCure, New York, NY, USA.
PubMed PMC DOI PDF

Abstract

Measurement of adherence to oral pre-exposure prophylaxis (PrEP) in real-time has been challenging. We developed DOT Diary, a smartphone application that combines automated directly observed therapy with a PrEP adherence visualization toolkit, and tested its ability to measure PrEP adherence and to increase adherence among a diverse cohort of young men who have sex with men (MSM). We enrolled 100…

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