Proton export upregulates aerobic glycolysis.

Shonagh Russell^1,2, Liping Xu³, Yoonseok Kam⁴, Dominique Abrahams³, Bryce Ordway^3,5, Alex S Lopez⁶, Marilyn M Bui^6,7, Joseph Johnson⁷, Tamir Epstein⁸, Epifanio Ruiz⁹, Mark C Lloyd¹⁰, Pawel Swietach¹¹, Daniel Verduzco³, Jonathan Wojtkowiak³, Robert J Gillies³

¹Cancer Physiology, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA. Shonagh.russell@duke.edu.

²Graduate School, University of South Florida, 4202 E Fowler Ave, Tampa, FL, 33620, USA. Shonagh.russell@duke.edu.

³Cancer Physiology, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA.

⁴Agilent Technologies, 5301 Stevens Creek Blvd, Santa Clara, CA, 9505, USA.

⁵Graduate School, University of South Florida, 4202 E Fowler Ave, Tampa, FL, 33620, USA.

⁶Anatomic Pathology, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA.

⁷Analytic Microscopy Core, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA.

⁸, Mariotteplein 42, 1098PA, Amsterdam, the Netherlands.

⁹Small Animal Imaging Department, Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA.

¹⁰Inspirata, Inc., One North Dale Mabry Hwy. Suite 600, Tampa, FL, 33609, USA.

¹¹Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

PubMed PMC DOI PDF

Abstract

INTRODUCTION: Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the "Warburg Effect." It is widely assumed that this is a consequence of the upregulation of glycolytic enzymes. Oncogenic drivers can increase the expression of most proteins in the glycolytic pathway, including the terminal step of export…

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