Peer-Reviewed Publication
Magn Reson Med2022;88(3):1039-1054.September 1, 2022Journal Article
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.
Xiaoxi Liu1, Shuyu Tang2, Changhua Mu1, Hecong Qin1, Di Cui1, Ying-Chieh Lai1,3, Andrew M Riselli1, Romelyn Delos Santos1, Lucas Carvajal1, Daniel Gebrezgiabhier1, Robert A Bok1, Hsin-Yu Chen1, Robert R Flavell1, Jeremy W Gordon1, Daniel B Vigneron1,4, John Kurhanewicz1,4, Peder E Z Larson1,4
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
2HeartVista, Los Altos, California, USA.
3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
4Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.
Abstract
PURPOSE: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized 13 C-MRI human study with injection of co-hyperpolarized […
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