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Peer-Reviewed Publication
Genes (Basel)2022;13(4)April 13, 2022Journal Article

Additive and Interactive Genetically Contextual Effects of HbA1c on cg19693031 Methylation in Type 2 Diabetes.

Kelsey Dawes1, Willem Philibert1, Benjamin Darbro2, Ronald L Simons3, Robert Philibert1,4,5
1Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
2Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
3Department of Sociology, University of Georgia, Athens, GA 30602, USA.
4Behavioral Diagnostics LLC, Coralville, IA 52246, USA.
5Cardio Diagnostics Inc., Coralville, IA 52246, USA.
PubMed PMC DOI PDF

Abstract

Type 2 diabetes mellitus (T2D) has a complex genetic and environmental architecture that underlies its development and clinical presentation. Despite the identification of well over a hundred genetic variants and CpG sites that associate with T2D, a robust biosignature that could be used to prevent or forestall clinical disease has not been developed. Based on the premise that underlying genetic v…

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