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Peer-Reviewed Publication
Circ Res2022;130(10):1510-1530.May 13, 2022Journal Article

Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.

Roshni Roy Chowdhury1,2, Jessica D'Addabbo3, Xianxi Huang4, Stefan Veizades3,5,6,7, Koki Sasagawa3, David M Louis8, Paul Cheng3,5, Jan Sokol3,5, Annie Jensen3,5,8, Alexandria Tso3,5,8, Vishnu Shankar8, Ben Shogo Wendel8, Isaac Bakerman3,5, Grace Liang3,5, Tiffany Koyano9, Robyn Fong9, Allison N Nau8, Herra Ahmad10, Jayakrishnan Gopakumar10, Robert Wirka11, Andrew S Lee12, Jack Boyd9, Y Joseph Woo9, Thomas Quertermous3,5, Gunsagar Singh Gulati13, Siddhartha Jaiswal10, Yueh-Hsiu Chien1, Charles Kwok Fai Chan5,13, Mark M Davis1,8,14, Patricia K Nguyen3,5,8
1Department of Microbiology and Immunology (R.R.C., Y.-H.C., M.M.D.), Stanford University, Stanford, CA, USA.
2CA, Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago' IL (R.R.C.).
3Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
4Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Guangdong, China (X.H.).
5Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
6Edinburgh Medical School, United Kingdom (S.V.).
7Centre for Inflammation Research, University of Edinburgh, Scotland (S.V.).
8Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
9Department of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
10Department of Pathology (H.A., J.G., S.J.), Stanford University, Stanford, CA, USA.
11Department of Medicine and Cell Biology and Physiology, and McAllister Heart Institute, University of North Carolina-Chapel Hill, NC (R.W.).
12Institute for Cancer Research, Shenzhen Bay Labs, China (A.S.L.).
13Institute for Stem Cell Biology and Regenerative Medicine (G.S.G., C.C.), Stanford University, Stanford, CA, USA.
14Howard Hughes Medical Institute (M.M.D.), Stanford University, Stanford, CA, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to d…

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