Efficacy and safety of high versus standard dose ibuprofen for patent ductus arteriosus treatment in preterm infants: A systematic review and meta-analysis.

T Yeung^1,2,3, M Shahroor^1,4, A Jain^1,3, D Weisz^1,4, B Jasani^1,5

¹Department of Pediatrics, Division of Neonatology, University of Toronto, Toronto, Canada.

²Windsor Regional Hospital, Windsor, Canada.

³Mount Sinai Hospital, Toronto, Canada.

⁴Sunny brook Health Sciences Centre, Toronto, Canada.

⁵The Hospital for Sick Children, Toronto, Canada.

PubMed DOI

Abstract

BACKGROUND: Several small randomized controlled trials (RCTs) and observational studies have compared high (15-20/7.5-10/7.5-10 mg/kg/dose) versus standard dose (10/5/5 mg/kg/dose) ibuprofen for patent ductus arteriosus (PDA) closure, with limited evidence on efficacy and safety. OBJECTIVE: To systematically review and meta-analyze studies of high versus standard dose ibuprofen for the closure of…

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