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Peer-Reviewed Publication
Hum Brain Mapp2022;43(10):3221-3244.July 1, 2022Journal Article

Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.

Paul Alexander Bloom1, Michelle VanTieghem2, Laurel Gabard-Durnam3, Dylan G Gee4, Jessica Flannery5, Christina Caldera6, Bonnie Goff6, Eva H Telzer7, Kathryn L Humphreys8, Dominic S Fareri9, Mor Shapiro10, Sameah Algharazi11, Niall Bolger1, Mariam Aly1, Nim Tottenham1
1Department of Psychology, Columbia University, New York, New York, USA.
2Virta Health, San Francisco, California, USA.
3Department of Psychology, Northeastern University, Boston, Massachusetts, USA.
4Department of Psychology, Yale University, New Haven, Connecticut, USA.
5Limbix Health, San Francisco, California, USA.
6Department of Psychology, University of California Los Angeles, Los Angeles, California, USA.
7University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
8Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
9Department of Psychology, Adelphi University, Garden City, New York, USA.
10Kaiser Permanente, Oakland, California, USA.
11Department of Psychology, City College of New York, New York, New York, USA.

Abstract

The amygdala and its connections with medial prefrontal cortex (mPFC) play central roles in the development of emotional processes. While several studies have suggested that this circuitry exhibits functional changes across the first two decades of life, findings have been mixed - perhaps resulting from differences in analytic choices across studies. Here we used multiverse analyses to examine the…

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