Biomarker LEPRE1 induces pelitinib-specific drug responsiveness by regulating ABCG2 expression and tumor transition states in human leukemia and lung cancer.

A-Ram Lee^1,2, Sunho Lee^3,4, Jee Yoon Shin³, Ji-Young Kim¹, Kyoung-Sik Moon⁵, Joungsun Jung⁶

¹Department of Advanced Toxicology, Korea Institute of Toxicology (KIT), Daejeon, 34114, Republic of Korea.

²Bio Center, LegoChem Biosciences, Inc., Daejeon, 34002, Republic of Korea.

³Genome Data Integration Centre, Syntekabio Inc., Daejeon, 34025, Republic of Korea.

⁴Department of Computer Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

⁵Department of Advanced Toxicology, Korea Institute of Toxicology (KIT), Daejeon, 34114, Republic of Korea. ksmoon@kitox.re.kr.

⁶Genome Data Integration Centre, Syntekabio Inc., Daejeon, 34025, Republic of Korea. jung@syntekabio.com.

PubMed PMC DOI PDF

Abstract

Biomarkers for treatment sensitivity or drug resistance used in precision medicine include prognostic and predictive molecules, critical factors in selecting appropriate treatment protocols and improving survival rates. However, identification of accurate biomarkers remain challenging due to the high risk of false-positive findings and lack of functional validation results for each biomarker. Here…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Mentioned Companies

Syntekabio
affiliation

MeSH Terms

ATP Binding Cassette Transporter, Subfamily G, Member 20Aminoquinolines0Aniline Compounds0Antineoplastic Agents0Biomarkers, Tumor*Cell Line, Tumor0Drug Resistance, Neoplasm0Epithelial-Mesenchymal Transition0Gene Expression Regulation, Leukemic0Gene Expression Regulation, Neoplastic0Humans0Leukemia, Myeloid, Acute0Lung Neoplasms0Membrane Glycoproteins0Neoplasm Proteins0Prolyl Hydroxylases0Proteoglycans0

Article Info

PMID: 35190588
PMCID: PMC8861100
DOI: 10.1038/s41598-022-06621-w
Received: August 9, 2021
Accepted: January 28, 2022

How to Cite

Lee AR et al. Biomarker LEPRE1 induces pelitinib-specific drug responsiveness by regulating ABCG2 expression and tumor transition states in human leukemia and lung cancer. Sci Rep2022;12(1):2928. doi:10.1038/s41598-022-06621-w

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.