Health AI Central
Peer-Reviewed Publication
J Neurosci2022;42(12):2503-2515.March 23, 2022Journal Article

Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.

Heta Helakari1,2,3, Vesa Korhonen4,2,3, Sebastian C Holst5, Johanna Piispala2,3,6, Mika Kallio2,3,6, Tommi Väyrynen4,2,3, Niko Huotari4,2,3, Lauri Raitamaa4,2,3, Johanna Tuunanen4,2,3, Janne Kananen4,2,3, Matti Järvelä4,2,3, Timo Tuovinen4,2,3, Ville Raatikainen4,2,3, Viola Borchardt4,2,3, Hannu Kinnunen7, Maiken Nedergaard8,9, Vesa Kiviniemi1,2,3
1Oulu Functional Neuroimaging, Department of Diagnostic Radiology, Oulu University Hospital, 90220 Oulu, Finland vesa.kiviniemi@oulu.fi heta.helakari@oulu.fi.
2Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, 90220 Oulu, Finland.
3Medical Research Center, Oulu University Hospital, 90220 Oulu, Finland.
4Oulu Functional Neuroimaging, Department of Diagnostic Radiology, Oulu University Hospital, 90220 Oulu, Finland.
5Neurobiology Research Unit, University of Copenhagen, 2200 Copenhagen, Denmark.
6Clinical Neurophysiology, Oulu University Hospital, 90220 Oulu, Finland.
7Oura Health, 90590 Oulu, Finland.
8Center of Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark.
9Center of Translational Neuromedicine, University of Rochester, Rochester, New York 14642.
PubMed PMC DOI PDF

Abstract

The physiological underpinnings of the necessity of sleep remain uncertain. Recent evidence suggests that sleep increases the convection of cerebrospinal fluid (CSF) and promotes the export of interstitial solutes, thus providing a framework to explain why all vertebrate species require sleep. Cardiovascular, respiratory and vasomotor brain pulsations have each been shown to drive CSF flow along p…

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