Health AI Central
Peer-Reviewed Publication
Nat Commun2022;13(1):662.February 3, 2022Journal Article

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis.

David A Spencer1,2, Benjamin S Goldberg3, Shilpi Pandey1, Tracy Ordonez1, Jérémy Dufloo4,5, Philip Barnette1, William F Sutton1, Heidi Henderson1, Rebecca Agnor6, Lina Gao6, Timothée Bruel4,7, Olivier Schwartz4,7, Nancy L Haigwood1,8, Margaret E Ackerman3, Ann J Hessell9
1Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
2Absci Corp, 1810 SE Mill Plain Blvd., Vancouver, WA, 98683, USA.
3Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
4Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
5Institute for Integrative Systems Biology, University of Valencia-CSIC, Calle Catedràtic Agustín Escardino Benlloch 9, 46980, Paterna, Valencia, Spain.
6Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
7Vaccine Research Institute, Creteil, France.
8Department of Molecular Microbiology & Immunology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
9Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. hessell@ohsu.edu.
PubMed PMC DOI PDF

Abstract

Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser extent Fc-mediated effector functions. It remains unclear whether augmenting effector functions of broadly neutralizing antibodies (bNAbs) may improve their clinical potential. Here, we use bNAb 10E8v4 target…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.