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Peer-Reviewed Publication
Nature2022;601(7893):422-427.January 1, 2022Journal Article

RNA profiles reveal signatures of future health and disease in pregnancy.

Morten Rasmussen1, Mitsu Reddy2, Rory Nolan2, Joan Camunas-Soler2, Arkady Khodursky2, Nikolai M Scheller3, David E Cantonwine4, Line Engelbrechtsen5, Jia Dai Mi6, Arup Dutta7, Tiffany Brundage2, Farooq Siddiqui2, Mainou Thao2, Elaine P S Gee2, Johnny La2, Courtney Baruch-Gravett8, Mark K Santillan9, Saikat Deb7,10, Shaali M Ame10, Said M Ali10, Melanie Adkins11, Mark A DePristo12, Manfred Lee2, Eugeni Namsaraev2, Dorte Jensen Gybel-Brask13,14, Lillian Skibsted13, James A Litch8, Donna A Santillan9, Sunil Sazawal7, Rachel M Tribe6, James M Roberts15, Maneesh Jain2, Estrid Høgdall14, Claudia Holzman11, Stephen R Quake16,17,18, Michal A Elovitz19,20, Thomas F McElrath21
1Mirvie, Inc., South San Francisco, CA, USA. morten@mirvie.com.
2Mirvie, Inc., South San Francisco, CA, USA.
3Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
4Brigham and Women's Hospital, Boston, MA, USA.
5Department of Obstetrics and Gynecology, Herlev University Hospital, Herlev, Denmark.
6Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital Campus, London, UK.
7Center for Public Health Kinetics, New Delhi, India.
8Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), Lynnwood, WA, USA.
9Department of Obstetrics & Gynecology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
10Public Health Laboratory-Idc, Pemba, Zanzibar, Tanzania.
11Michigan State University, East Lansing, MI, USA.
12BigHat Biosciences, Inc., San Mateo, CA, USA.
13Department of Obstetrics, Zealand University Hospital, Roskilde, Denmark.
14Department of Pathology, Herlev University Hospital, Herlev, Denmark.
15Magee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research University of Pittsburgh, Pittsburgh, PA, USA.
16Department of Bioengineering, Stanford University, Stanford, CA, USA.
17Chan Zuckerberg Biohub, Stanford, CA, USA.
18Department of Applied Physics, Stanford University, Stanford, CA, USA.
19Mirvie, Inc., South San Francisco, CA, USA. elovitz@pennmedicine.upenn.edu.
20Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. elovitz@pennmedicine.upenn.edu.
21Brigham and Women's Hospital, Boston, MA, USA. tmcelrath@bwh.harvard.edu.
PubMed PMC DOI PDF

Abstract

Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden1. Yet the ability to assess underlying pathophysiology before clinical presentation to enable identification of pregnancies at risk remains elusive. Here we demonstrate the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developi…

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