Microvilli Adhesion: An Alternative Route for Nanoparticle Cell Internalization.

Patrizia Sommi¹, Agostina Vitali², Stefania Coniglio¹, Daniele Callegari², Sofia Barbieri³, Alberto Casu⁴, Andrea Falqui⁴, Lorenzo Vigano'², Barbara Vigani⁵, Franca Ferrari⁵, Umberto Anselmi-Tamburini²

¹Human Physiology Unit, Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100 Pavia, Italy.

²Department of Chemistry, University of Pavia, 27100 Pavia, Italy.

³Department of Physics, University of Pavia, 27100 Pavia, Italy.

⁴Biological and Environmental Sciences and Engineering Division, NABLA Lab, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia.

⁵Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.

PubMed PMC DOI PDF

Abstract

The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediat…

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