Can quantitative analysis of multi-parametric MRI independently predict failure of focal salvage HIFU therapy in men with radio-recurrent prostate cancer?

Arnas Rakauskas¹, Taimur T Shah², Max Peters³, Jagpal S Randeva², Feargus Hosking-Jervis², Michael J Schmainda⁴, Clement Orczyck⁵, Mark Emberton⁵, Manit Arya⁵, Caroline Moore⁵, Hashim U Ahmed²

¹Imperial Prostate, Division of Surgery, Department of Surgery and Cancer, Imperial College, London, UK. Electronic address: Rakauskas.arn@gmail.com.

²Imperial Prostate, Division of Surgery, Department of Surgery and Cancer, Imperial College, London, UK.

³Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.

⁴Imaging Biometrics, LLC, Wisconsin, USA.

⁵Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.

PubMed PMC DOI PDF

Abstract

OBJECTIVES: Focal salvage HIFU is a feasible therapeutic option in some men who have recurrence after primary radiotherapy for prostate cancer. We aimed to determine if multi-parametric quantitative parameters, in addition to clinical factors, might have a role in independently predicting focal salvage HIFU outcomes. METHODS: A retrospective registry analysis included 150 consecutive men who unde…

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