A North American prospective study of depression, psychotropic medication use, and semen quality.

Jennifer J Yland¹, Michael L Eisenberg², Elizabeth E Hatch³, Kenneth J Rothman⁴, Craig J McKinnon³, Yael I Nillni⁵, Greg J Sommer⁶, Tanran R Wang³, Lauren A Wise³

¹Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts. Electronic address: yland@bu.edu.

²Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California; Department of Urology, Stanford University School of Medicine, Stanford, California.

³Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.

⁴Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts; RTI Health Solutions, Research Triangle, North Carolina.

⁵Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts; National Center for PTSD, Women's Health Sciences Division at VA Boston Healthcare System, Boston, Massachusetts.

⁶Sandstone Diagnostics, Inc., Pleasanton, California.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: To evaluate the associations of a history of diagnosed depression, current depressive symptoms, and recent use of psychotropic medications with semen quality and to consider mediation of the association between depression and semen quality by medication use. DESIGN: Prospective cohort study. SETTING: United States. PATIENT(S): The patients were 329 men aged ≥21 years (566 semen sampl…

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Mentioned Companies

Sandstone Diagnostics
affiliation

NIH Funding

Grant #11321641
An internet-based preconception cohort study in North America
BOSTON UNIVERSITY MEDICAL CAMPUS
$647,293 (FY2026)
Grant #11089499
A prospective study of male factors, fertility, and pregnancy outcomes
BOSTON UNIVERSITY MEDICAL CAMPUS
$663,115 (FY2025)
Grant #9607109
Feasibility of in-home semen testing in a North American preconception cohort study
BOSTON UNIVERSITY MEDICAL CAMPUS
$163,064 (FY2019)

Other Funding

NICHD NIH HHS(K23 HD087428)
United States
NICHD NIH HHS(R01 HD086742)
United States
NICHD NIH HHS(R01 HD105863)
United States
NICHD NIH HHS(R21 HD094322)
United States

MeSH Terms

Adult0Major Depressive Disorder0Humans0Male0Prospective Studies0Psychotropic Drugs0Sperm Count0Sperm Motility0Spermatozoa0United States0Young Adult0

Keywords

Depressionpsychotropic medicationssemen analysis

Article Info

PMID: 33966888
PMCID: PMC8410630
DOI: 10.1016/j.fertnstert.2021.03.052
Received: November 13, 2020
Accepted: March 31, 2021

How to Cite

Yland JJ et al. A North American prospective study of depression, psychotropic medication use, and semen quality. Fertil Steril2021;116(3):833-842. doi:10.1016/j.fertnstert.2021.03.052

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