Histological Severity Risk Factors Identification in Juvenile-Onset Recurrent Respiratory Papillomatosis: How Immunohistochemistry and AI Algorithms Can Help?

Charles Lépine^1,2, Paul Klein³, Thibault Voron¹, Marion Mandavit¹, Dominique Berrebi⁴, Sophie Outh-Gauer^1,2, Hélène Péré^1,5, Louis Tournier⁴, Franck Pagès⁶, Eric Tartour^1,6, Thomas Le Meur³, Sylvain Berlemont³, Natacha Teissier⁷, Mathilde Carlevan⁸, Nicolas Leboulanger⁸, Louise Galmiche⁹, Cécile Badoual^1,2

¹INSERM-U970, PARCC, Université de Paris, Paris, France.

²Department of Pathology, Hôpital Européen Georges-Pompidou, APHP, Paris, France.

³KeenEye, Paris, France.

⁴Department of Pathology, Hôpital Robert Debré, APHP, Paris, France.

⁵Department of Virology, Hôpital Européen Georges-Pompidou, APHP, Paris, France.

⁶Department of Immunology, Hôpital Européen Georges-Pompidou, APHP, Paris, France.

⁷Department of Pediatric ENT Surgery, Hôpital Robert Debré, APHP, Paris, France.

⁸Department of Pediatric ENT Surgery, Hôpital Necker-Enfants Malades, APHP, Paris, France.

⁹Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris, France.

PubMed PMC DOI PDF

Abstract

Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a condition characterized by the repeated growth of benign exophytic papilloma in the respiratory tract. The course of the disease remains unpredictable: some children experience minor symptoms, while others require multiple interventions due to florid growth. Our study aimed to identify histologic severity risk factors in patients wit…

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