Peer-Reviewed Publication
Methods Mol Biol2021;2225107-123.January 1, 2021Journal Article
Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins).
Jordan R Yaron1, Liqiang Zhang1, Michelle Burgin1, Lauren N Schutz1, Enkidia A Awo1, Shahar Keinan2, Grant McFadden3,4, Sriram Ambadapadi1,4, Qiuyun Guo1,5, Hao Chen6, Alexandra R Lucas7,8,9
1Centers for Personalized Diagnostics and for Immunotherapy, Vaccines and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
2Polaris Quantum Biotech, Durham, NC, USA.
3Center for Immunotherapy, Vaccines and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
4Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA.
5Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
6The Department of Tumor Surgery, Second Hospital of Lanzhou University, Lanzhou, China.
7Centers for Personalized Diagnostics and for Immunotherapy, Vaccines and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ, USA. arlucas5@asu.edu.
8Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA. arlucas5@asu.edu.
9St Joseph Hospital, Dignity Health, Creighton University, Phoenix, AZ, USA. arlucas5@asu.edu.
Abstract
Viruses have devised highly effective approaches that modulate the host immune response, blocking immune responses that are designed to eradicate viral infections. Over millions of years of evolution, virus-derived immune-modulating proteins have become extraordinarily potent, in some cases working at picomolar concentrations when expressed into surrounding tissues and effectively blocking host de…
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