Peer-Reviewed Publication
Nat Neurosci2020;23(12):1456-1468.December 1, 2020Journal Article
A community-based transcriptomics classification and nomenclature of neocortical cell types.
Rafael Yuste1, Michael Hawrylycz2, Nadia Aalling3, Argel Aguilar-Valles4, Detlev Arendt5, Ruben Armañanzas6,7, Giorgio A Ascoli6, Concha Bielza8, Vahid Bokharaie9, Tobias Borgtoft Bergmann3, Irina Bystron10, Marco Capogna11, YoonJeung Chang12, Ann Clemens13, Christiaan P J de Kock14, Javier DeFelipe15, Sandra Esmeralda Dos Santos16, Keagan Dunville17, Dirk Feldmeyer18, Richárd Fiáth19, Gordon James Fishell20, Angelica Foggetti21, Xuefan Gao22, Parviz Ghaderi23, Natalia A Goriounova14, Onur Güntürkün24, Kenta Hagihara25, Vanessa Jane Hall3, Moritz Helmstaedter26, Suzana Herculano-Houzel16, Markus M Hilscher27,28, Hajime Hirase3, Jens Hjerling-Leffler27, Rebecca Hodge29, Josh Huang30, Rafiq Huda31, Konstantin Khodosevich3, Ole Kiehn32, Henner Koch33, Eric S Kuebler34, Malte Kühnemund35, Pedro Larrañaga8, Boudewijn Lelieveldt36, Emma Louise Louth11, Jan H Lui37, Huibert D Mansvelder14, Oscar Marin38, Julio Martinez-Trujillo39, Homeira Moradi Chameh40, Alok Nath Mohapatra41, Hermany Munguba27, Maiken Nedergaard42, Pavel Němec43, Netanel Ofer44, Ulrich Gottfried Pfisterer3, Samuel Pontes45, William Redmond46, Jean Rossier47, Joshua R Sanes48, Richard H Scheuermann49,50, Esther Serrano-Saiz51, Jochen F Staiger52, Peter Somogyi10, Gábor Tamás53, Andreas Savas Tolias54, Maria Antonietta Tosches45, Miguel Turrero García55, Christian Wozny56,57, Thomas V Wuttke58, Yong Liu3, Juan Yuan27, Hongkui Zeng59, Ed Lein60
1Columbia University, New York City, NY, USA. rmy5@columbia.edu.
2Allen Institute for Brain Science, Seattle, WA, USA. MikeH@alleninstitute.org.
3University of Copenhagen, Copenhagen, Denmark.
4Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
5European Molecular Biology Laboratory, Heidelberg, Germany.
6George Mason University, Fairfax, VA, USA.
7BrainScope Company Inc., Bethesda, MD, USA.
8Universidad Politécnica de Madrid, Madrid, Spain.
9Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
10University of Oxford, Oxford, UK.
11Department of Biomedicine, Aarhus University, Aarhus, Denmark.
12Department of Genetics, Harvard Medical School, Boston, MA, USA.
13The University of Edinburgh, Edinburgh, UK.
14Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
15Cajal Institute, Madrid, Spain.
16Vanderbilt University, Nashville, TN, USA.
17Scuola Normale Superior, Pisa, Italy.
18Research Centre Jülich, Jülich, Germany.
19Research Centre for Natural Sciences, Budapest, Hungary.
20Harvard Medical School, Cambridge, MA, USA.
21Christian-Albrechts-University Kiel, Kiel, Germany.
22European Molecular Biology Laboratory, Hamburg, Germany.
23École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
24Ruhr University Bochum, Bochum, Germany.
25Friedrich Miescher Institute for Biological Research, Basel, Switzerland.
26Max Planck Institute for Brain Research, Frankfurt, Germany.
27Karolinska Institutet, Stockholm, Sweden.
28Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.
29Allen Institute for Brain Science, Seattle, WA, USA.
30Cold Spring Harbor Laboratory, Laurel Hollow, NY, USA.
31WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University - New Brunswick, Piscataway, NJ, USA.
32Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
33RWTH Aachen University, Aachen, Germany.
34Robarts Research Institute, Western University, London, Ontario, Canada.
35CARTANA, Stockholm, Sweden.
36Leiden University Medical Center, Leiden, the Netherlands.
37Stanford University, Stanford, CA, USA.
38King's College London, London, UK.
39Schulich School of Medicine and Dentistry, Departments of Physiology, Pharmacology and Psychiatry, University of Western Ontario, London, Ontario, Canada.
40Krembil Research Institute, Toronto, Ontario, Canada.
41University of Haifa, Haifa, Israel.
42Univeristy of Rochester, Rochester, NY, USA.
43Charles University, Prague, Czech Republic.
44Bar Ilan University, Ramat Gan, Israel.
45Columbia University, New York City, NY, USA.
46Macquarie University, Sydney, New South Wales, Australia.
47Sorbonne University, Paris, France.
48Harvard University, Cambridge, MA, USA.
49J. Craig Venter Institute, La Jolla, CA, USA.
50Department of Pathology, University of California, San Diego, CA, USA.
51Centro de Biologia Molecular Severo Ochoa (CSIC), Madrid, Spain.
52Institute for Neuroanatomy, University of Göttingen, Göttingen, Germany.
53University of Szeged, Szeged, Hungary.
54Baylor College of Medicine, Houston, TX, USA.
55Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
56University of Strathclyde, Glasgow, UK.
57MSH Medical School, Hamburg, Germany.
58Departments of Neurosurgery and of Neurology and Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
59Allen Institute for Brain Science, Seattle, WA, USA. HongkuiZ@alleninstitute.org.
60Allen Institute for Brain Science, Seattle, WA, USA. EdL@alleninstitute.org.
Abstract
To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal or glial cell types, partly due to limited data. Single-cell transcriptomics is enabling, for the first time, systematic high-throughput measurements o…
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