Peer-Reviewed Publication
Sci Adv2020;6(28):eaba1983.July 1, 2020Journal Article
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.
Taylor S Adams1, Jonas C Schupp1, Sergio Poli2, Ehab A Ayaub2, Nir Neumark1,3, Farida Ahangari1, Sarah G Chu2, Benjamin A Raby2,4,5, Giuseppe DeIuliis1, Michael Januszyk6, Qiaonan Duan6, Heather A Arnett6, Asim Siddiqui6, George R Washko2, Robert Homer7,8, Xiting Yan1, Ivan O Rosas2, Naftali Kaminski1
1Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
2Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
4Division of Pulmonary Medicine, Boston's Children Hospital, Harvard Medical School, Boston, MA, USA.
5Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
6NuMedii, Inc., San Mateo, CA, USA.
7Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
8Pathology and Laboratory Medicine Service and VA CT HealthCare System, West Haven, CT, USA.
Abstract
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Among epithelial cells enriched in IPF, we identify a previously unidentified population of aberrant basaloid cells that coexpress basal epithelial, mesenchymal,…
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