The My Cancer Genome clinical trial data model and trial curation workflow.

Neha Jain¹, Kathleen F Mittendorf¹, Marilyn Holt¹, Michele Lenoue-Newton¹, Ian Maurer², Clinton Miller², Matthew Stachowiak², Michelle Botyrius², James Cole², Christine Micheel^1,3, Mia Levy^4,5

¹Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

²GenomOncology LLC, Cleveland, Ohio, USA.

³Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

⁴Department of Internal Medicine, Division of Hematology/Oncology, Rush University Medical Center, Chicago, Illinois, USA.

⁵Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: As clinical trials evolve in complexity, clinical trial data models that can capture relevant trial data in meaningful, structured annotations and computable forms are needed to support accrual. MATERIAL AND METHODS: We have developed a clinical trial information model, curation information system, and a standard operating procedure for consistent and accurate annotation of cancer clin…

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