A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner.

Shuyu Tang^1,2, Robert Bok², Hecong Qin^1,2, Galen Reed³, Mark VanCriekinge², Romelyn Delos Santos², William Overall², Juan Santos², Jeremy Gordon², Zhen Jane Wang^1,2, Daniel B Vigneron^1,2, Peder E Z Larson^1,2

¹UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.

²Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.

³HeartVista, Los Altos, CA, USA.

PubMed PMC DOI PDF

Abstract

PURPOSE: The balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized 13C magnetization, but suffers from poor spectral selectivity and long acquisition time. The purpose of this study was to develop a novel metabolite-specific 3D bSSFP ("MS-3DSSFP") sequence with stack-of-spiral readouts for improved lactate imaging…

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