Peer-Reviewed Publication
Chronic Obstr Pulm Dis2019;6(5):384-399.November 1, 2019Journal Article
COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.
Katherine E Lowe1, Elizabeth A Regan2, Antonio Anzueto3, Erin Austin4, John H M Austin5, Terri H Beaty6, Panayiotis V Benos7, Christopher J Benway8, Surya P Bhatt9, Eugene R Bleecker10, Sandeep Bodduluri9, Jessica Bon7,11, Aladin M Boriek12, Adel Re Boueiz8, Russell P Bowler2, Matthew Budoff13, Richard Casaburi13, Peter J Castaldi8, Jean-Paul Charbonnier14, Michael H Cho8, Alejandro Comellas15, Douglas Conrad16, Corinne Costa Davis17, Gerard J Criner18, Douglas Curran-Everett2, Jeffrey L Curtis19, Dawn L DeMeo8, Alejandro A Diaz8, Mark T Dransfield9, Jennifer G Dy20, Ashraf Fawzy6, Margaret Fleming21, Eric L Flenaugh22, Marilyn G Foreman22, Spyridon Fortis15, Hirut Gebrekristos22, Sarah Grant21, Philippe A Grenier23, Tian Gu24, Abhya Gupta25, MeiLan K Han24, Nicola A Hanania12, Nadia N Hansel6, Lystra P Hayden8, Craig P Hersh8, Brian D Hobbs8, Eric A Hoffman15, James C Hogg26, John E Hokanson27, Karin F Hoth15, Albert Hsiao28, Stephen Humphries2, Kathleen Jacobs16, Francine L Jacobson8, Ella A Kazerooni24, Victor Kim18, Woo Jin Kim29, Gregory L Kinney27, Harald Koegler30, Sharon M Lutz31, David A Lynch2, Neil R MacIntye32, Barry J Make2, Nathaniel Marchetti18, Fernando J Martinez33, Diego J Maselli3, Anne M Mathews32, Meredith C McCormack6, Merry-Lynn N McDonald9, Charlene E McEvoy34, Matthew Moll8, Sarah S Molye35, Susan Murray24, Hrudaya Nath9, John D Newell15,36,37, Mariaelena Occhipinti38, Matteo Paoletti38, Trisha Parekh9, Massimo Pistolesi38, Katherine A Pratte2, Nirupama Putcha6, Margaret Ragland27, Joseph M Reinhardt15, Stephen I Rennard39,40, Richard A Rosiello41, James C Ross8, Harry B Rossiter13,42, Ingo Ruczinski6, Raul San Jose Estepar8, Frank C Sciurba7, Jessica C Sieren15, Harjinder Singh3, Xavier Soler16,43, Robert M Steiner18, Matthew J Strand2, William W Stringer13, Ruth Tal-Singer44, Byron Thomashow5, Gonzalo Vegas Sánchez-Ferrero8, John W Walsh45, Emily S Wan8,46, George R Washko8, J Michael Wells9, Chris H Wendt47, Gloria Westney22, Ava Wilson9, Robert A Wise6, Andrew Yen16, Kendra Young27, Jeong Yun8, Edwin K Silverman8, James D Crapo2
1Cleveland Clinic Lerner College of Medicine of Case Western Reserve School of Medicine, Cleveland, Ohio.
2National Jewish Health, Denver, Colorado.
3University of Texas Health, San Antonio.
4University of Colorado at Denver.
5Columbia University, New York.
6Johns Hopkins University, Baltimore, Maryland.
7University of Pittsburgh, Pittsburgh, Pennsylvania.
8Brigham and Women's Hospital, Boston, Massachusetts.
9University of Alabama at Birmingham.
10University of Arizona Health Sciences, Tucson.
11VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
12Baylor College of Medicine, Houston, Texas.
13Los Angeles Biomedical Research Institute at Harbor- University of California Los Angeles Medical Center, Torrance.
14Thirona, Nijmegen, The Netherlands.
15University of Iowa, Iowa City.
16University of California at San Diego.
17COPD Foundation, Washington, DC.
18Temple University, Philadelphia, Pennsylvania.
19Ann Arbor VA Medical Center, Ann Arbor, Michigan.
20Northeastern University, Boston, Massachusetts.
21Novartis Institute for Biomedical Research, Cambridge, Massachusetts.
22Morehouse School of Medicine, Atlanta, Georgia.
23Hôpital Foch, Suresnes, France.
24University of Michigan, Ann Arbor.
25Boehringer Ingelheim, Biberach an der Riss, Germany.
26University of British Columbia, Vancouver, Canada.
27University of Colorado Anschutz Medical Campus, Aurora.
28University of California-San Diego, La Jolla.
29Kangwon National University, Chuncheon, Korea.
30Boehringer-Ingelheim, Ingelheim, Germany.
31Harvard Medical School, Boston, Massachusetts.
32Duke University Health, Durham, North Carolina.
33Weill-Cornell Medicine, New York City, New York.
34Minnesota Health Partners, St. Paul.
35AstraZeneca, Denver, Colorado.
36University of Washington, Seattle.
37VIDA Diagnostics, Inc, Coralville, Iowa.
38University of Florence, Florence, Italy.
39AstraZeneca, Cambridge, United Kingdom.
40University of Nebraska Medical Center, Omaha.
41Reliant Medical Group, Worcester, Massachusetts.
42University of Leeds, Leeds, United Kingdom.
43GlaxoSmithKline, Research Triangle Park, North Carolina.
44GlaxoSmithKline, Collegeville, Pennsylvania.
45COPD Foundation, Miami, Florida, † deceased.
46VA Boston Healthcare System, Jamaica Plain, Massachusetts.
47Minneapolis VA, Minneapolis, Minnesota.
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need…
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