Placental cell death patterns exhibit differences throughout gestation in two strains of laboratory mice.

Jacqui Detmar^1,2,3, Isidora Rovic^1,4, Jocelyn Ray^1,4, Isabella Caniggia^1,2,4,5, Andrea Jurisicova^6,7,8,9

¹Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.

²Institute of Medical Sciences, University of Toronto, Toronto, Canada.

³MedAvail Technologies Inc., 6810 Meadowvale Town Centre Circle, Unit 18, Mississauga, ON, L5N 7T5, Canada.

⁴Department of Physiology, University of Toronto, Toronto, Canada.

⁵Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada.

⁶Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. jurisicova@lunenfeld.ca.

⁷Department of Physiology, University of Toronto, Toronto, Canada. jurisicova@lunenfeld.ca.

⁸Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada. jurisicova@lunenfeld.ca.

⁹Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 6-1016-1AJ, 25 Orde Street, Toronto, ON, M5T 3H7, Canada. jurisicova@lunenfeld.ca.

PubMed DOI

Abstract

Cell death is an essential physiological process required for the proper development and function of the human placenta. Although the mouse is a commonly used animal model for development studies, little is known about the extent and distribution of cell death in the mouse placenta throughout development and its physiological relevance. In the present study, we report the results of a systematic a…

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Mentioned Companies

MedAvail
affiliation

Other Funding

Natural Sciences and Engineering Research Council of Canada (CA)(RGPIN-04497)
Natural Sciences and Engineering Research Council of Canada (CA)(RGPIN-04497)
Canadian Institute of Health Research(MOP-89813)
Canadian Institute of Health Research(MOP-89813)

MeSH Terms

Animals0Caspase 30Cell Death0Female0Humans0Mice0Mice, Inbred C57BL0Mice, Inbred ICR0Models, Animal0Placenta*Pregnancy0Proto-Oncogene Proteins c-bcl-20

Keywords

BokCaspase-3Cell deathMurine placentaTUNEL

Article Info

PMID: 31227907
DOI: 10.1007/s00441-019-03055-1
Received: December 20, 2018
Accepted: May 28, 2019

How to Cite

Detmar J et al. Placental cell death patterns exhibit differences throughout gestation in two strains of laboratory mice. Cell Tissue Res2019;378(2):341-358. doi:10.1007/s00441-019-03055-1

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