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Peer-Reviewed Publication
Eur Radiol2019;29(12):6728-6740.December 1, 2019Journal Article

Optoacoustic imaging of the breast: correlation with histopathology and histopathologic biomarkers.

Gisela L G Menezes1, Ritse M Mann2, Carla Meeuwis3, Bob Bisschops4, Jeroen Veltman5, Philip T Lavin6, Marc J van de Vijver7, Ruud M Pijnappel8
1Seno Medical Instruments, 8023 Vantage Dr. #1000, San Antonio, TX, 78230, USA. giselalgm@gmail.com.
2Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
3Department of Radiology, Rijnstate Hospital, Wagnerlaan 55, 6815 AD, Arnhem, The Netherlands.
4Department of Radiology, Albert Schweitzer Hospital, Albert Schweitzerplaats 25, 3318 AT, Dordrecht, The Netherlands.
5Department of Radiology, ZGT, Zilvermeeuw 1, 7609 PP, Almelo, The Netherlands.
6Boston Biostatistics Research Foundation, 3 Cahill Park Drive, Framingham, MA, 01702, USA.
7Department of Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
8Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Abstract

AIM: This study was conducted in order to investigate the role of gray-scale ultrasound (US) and optoacoustic imaging combined with gray-scale ultrasound (OA/US) to better differentiate between breast cancer molecular subtypes. MATERIALS AND METHODS: All 67 malignant masses included in the Maestro trial were retrospectively reviewed to compare US and OA/US feature scores and histopathological fin…

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