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Peer-Reviewed Publication
Neurochem Res2020;45(1):42-52.January 1, 2020Journal Article

Reduction of Dimensionality in Monte Carlo Simulation of Diffusion in Extracellular Space Surrounding Cubic Cells.

Charles Nicholson1, Padideh Kamali-Zare2,3
1Department of Neuroscience and Physiology, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA. charles.nicholson@nyu.edu.
2Department of Neuroscience and Physiology, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA.
3Darmiyan Inc, 1 Sansome Street, Suite 3500, San Francisco, CA, 94104, USA.

Abstract

The real-time iontophoretic method has measured volume fraction and tortuosity of the interstitial component of extracellular space in many regions and under different conditions. To interpret these data computer models of the interstitial space (ISS) of the brain are constructed by representing cells as Basic Cellular Structures (BCS) surrounded by a layer of ISS and replicating this combination…

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