Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies.

Xiaoqing Li¹, Yong Lin², Ruizhi Zhang¹

¹1 Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, China.

²2 Department of Ultrasonic Cardiogram, Guangdong Provincial Hospital of Chinese Medicine, China.

Abstract

The roles of endothelial nitric oxide synthase gene polymorphisms in coronary artery disease have been intensively analyzed, with inconsistent results. Therefore, we performed this study to better assess the relationship between endothelial nitric oxide synthase genetic variations and the risk of coronary artery disease. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science…

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