Elevation of serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations and its possible atherogenic role in patients with systemic lupus erythematosus.

Chenglong Fang¹, Tingting Luo², Ling Lin¹

¹Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

²Department of Ultrasonic Cardiogram, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) patients have tendencies of accelerated atherosclerosis (AS) which can only partly be explained by traditional cardiovascular disease (CVD) risk factors. Imbalanced inflammation also plays a vital role. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new therapeutic target for AS for its dual mechanisms in lipids and inflammation. We aimed…

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