How well can familial hypercholesterolemia be identified in an electronic health record database?

Katherine E Mues¹, Alina N Bogdanov², Keri L Monda¹, Larisa Yedigarova³, Alexander Liede¹, Lee Kallenbach²

¹Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA, kmues@amgen.com.

²Practice Fusion, San Francisco, CA, USA.

³US Medical Affairs, Amgen Inc., Thousand Oaks, CA, USA.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Familial hypercholesterolemia (FH) is a condition characterized by high cholesterol levels and increased risk for coronary heart disease (CHD) that often goes undiagnosed. The Dutch Lipid Network Criteria (DLNC) are used to identify FH in clinical settings via physical examination, personal and family history of CHD, in addition to the presence of deleterious mutations of the LDLR, Apo…

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