Health AI Central
Peer-Reviewed Publication
Hum Brain Mapp2019;40(2):679-698.February 1, 2019Journal Article

Automatic localization of the subthalamic nucleus on patient-specific clinical MRI by incorporating 7 T MRI and machine learning: Application in deep brain stimulation.

Jinyoung Kim1, Yuval Duchin1, Reuben R Shamir1, Remi Patriat2, Jerrold Vitek3, Noam Harel1,2,4, Guillermo Sapiro1,5,6,7,8
1Surgical Information Sciences, Inc., Minneapolis, Minnesota.
2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.
3Department of Neurology, University of Minnesota, Minneapolis, Minnesota.
4Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota.
5Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina.
6Department of Biomedical Engineering, Duke University, Durham, North Carolina.
7Department of Computer Science, Duke University, Durham, North Carolina.
8Department of Mathematics, Duke University, Durham, North Carolina.
PubMed PMC DOI PDF

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has shown clinical potential for relieving the motor symptoms of advanced Parkinson's disease. While accurate localization of the STN is critical for consistent across-patients effective DBS, clear visualization of the STN under standard clinical MR protocols is still challenging. Therefore, intraoperative microelectrode recordings (MER…

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