Health AI Central
Peer-Reviewed Publication
Neurosurgery2019;84(3):749-757.March 1, 2019Journal Article

Microelectrode Recordings Validate the Clinical Visualization of Subthalamic-Nucleus Based on 7T Magnetic Resonance Imaging and Machine Learning for Deep Brain Stimulation Surgery.

Reuben R Shamir1, Yuval Duchin1,2, Jinyoung Kim3, Remi Patriat2, Odeya Marmor4, Hagai Bergman4,5, Jerrold L Vitek6, Guillermo Sapiro3,7, Atira Bick8, Ruth Eliahou8, Renana Eitan4,9, Zvi Israel10, Noam Harel2
1Surgical Information Sciences, Minneapolis, Minnesota.
2Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minnesota.
3Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina.
4Department of Neurobiology, Institute of Medical Research-Israel Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
5Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
6Department of Neurology, University of Minnesota, Minneapolis, Minnesota.
7Departments of Biomedical Engineering, Computer Science, and Mathematics, Duke University, Durham, North Carolina.
8Department of Radiology, Hadassah Medical Center, Jerusalem, Israel.
9Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
10Department of Neurosurgery, Hadassah Medical Center, Jerusalem, Israel.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a proven and effective therapy for the management of the motor symptoms of Parkinson's disease (PD). While accurate positioning of the stimulating electrode is critical for success of this therapy, precise identification of the STN based on imaging can be challenging. We developed a method to accurately visualize the STN…

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